Impact of a positive Chlamydia trachomatis serology on cumulative IVF live birth rate

Clara Gadenne (1) , Laura Miquel (2) , Cindy Faust (3) , Julie Berbis (3) , Jeanne Perrin (4, 5) , Blandine Courbiere (5, 6)

1 UR UFRS - Université de La Réunion - UFR Santé
2 Department of Obstetrics, Gynecology and Reproductive Medicine, "Women, parents and children unit," AP-HM La Conception University Hospital , Marseille, France.
3 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
4 LA CONCEPTION - Hôpital de la Conception [CHU - APHM]
5 IMBE - Institut méditerranéen de biodiversité et d'écologie marine et continentale
6 APHM - Assistance Publique - Hôpitaux de Marseille

Research question Does positive Chlamydia trachomatis serology have an impact on the cumulative live birth rate from IVF? Design A retrospective matched cohort study compared women with positive Chlamydia trachomatis serology (group A) who underwent IVF treatment between January 2016 and December 2021 with a control group of women with negative Chlamydia trachomatis serology (group B). The main outcome measures were the cumulative live birth rate per IVF cycle and the live birth rate per embryo transfer. Secondary outcomes were the cumulative rates of clinical pregnancy, ectopic pregnancy and pregnancy loss calculated per IVF cycle and per embryo transfer. Results A total of 151 women in group A were matched 1:2 to 302 women in group B, representing 220 and 440 IVF cycles, respectively. Women with a history of Chlamydia trachomatis infection had a significantly higher rate of tubal obstruction (P < 0.001), excluded or operated hydrosalpinx (P = 0.002) and/or history of chronic endometritis (P < 0.001). There were no statistically significant differences between the two groups in the mean number of mature oocytes retrieved, fertilization rate or implantation rate. The IVF cumulative live birth rate per cycle was similar in the two groups (36.7% in group A versus 34.9% in group B, P = 0.692). The cumulative rates of clinical pregnancy, pregnancy loss, biochemical pregnancy and ectopic pregnancy were comparable between the two groups. Conclusion Positive Chlamydia trachomatis serology has no impact on IVF pregnancy outcomes.

Keywords: Chlamydia trachomatis; Cumulative live birth rate; IVF; Pregnancy outcome

Domains: Human health and pathology

Clara Gadenne, Laura Miquel, Cindy Faust, Julie Berbis, Jeanne Perrin, et al.. Impact of a positive Chlamydia trachomatis serology on cumulative IVF live birth rate. Reproductive BioMedicine Online, 2024, 48 (2), pp.103586. ⟨10.1016/j.rbmo.2023.103586⟩. ⟨hal-04412334⟩